Bupropion is an antidepressant in a class by itself, somewhat different from other antidepressants (tricyclic antidepressants and selective serotonin reuptake inhibitors).
However, like other antidepressants, bupropion's effect in neuropathy has nothing to do with depression.
Rather, it has to do with drug's ability to interfere with chemical messengers, called neurotransmitters, in the brain.
This drug affects dopamine and norepinephrine, which in turn affects the way the brain perceives pain.
Zyban demonstrated greater effectiveness than placebo in a study in 46 patients with neuropathy due to various causes, according to Neurology.
Nearly 75% of patients rated their pain as improved or much improved with generic Zyban compared to no significant change with placebo.
A major benefit of this medication compared to selective serotonin reuptake inhibitors (SSRIs) is that it is less likely to cause negative sexual side effects.
Potential side effects
Dizziness, headache, insomnia, nausea, dry mouth, sore throat, chest pain, agitation, anxiety, memory decreased, nervousness, itching, rash, sweating increased, anorexia, constipation, diarrhea, taste perversion, urinary frequency, joint aches, arthritis, muscle aches, tremor, double vision, ringing in ears, cough increased, abdominal pain, increased heart rate, sedation.
- Inform your doctor if you have a history of seizures, anorexia, bulimia, liver or kidney dysfunction, high blood pressure, or heart disease.
- Do not use if you have used MAO inhibitors within 14 days or if you have suddenly stopped sedatives or chronic alcohol use.
- Elderly patients may need to be monitored while using this drug.
- Notify your doctor if you experience any changes in concentration or mental status.
- Wear protective clothing and sunscreen, as this drug has been associated with photosensitivity reactions (skin reactions related to sun exposure).
, sertraline, orphenadrine, thiotepa, cyclophosphamide, carbamazepine, nevirapine, phenobarbital, phenytoin, rifampin, amantadine, levodopa, tonavir, warfarin.
Valerian, St. John's wort, SAMe, gotu kola, kava kava.
Pregnancy and breast-feeding cautions
FDA Pregnancy Risk Category B. This drug is excreted in breast milk. Breast-feeding is not recommended during therapy with this drug.
Buy Zyban online
Where can I buy bupropion without prescription?
Zyban is a prescription drug that comes in 150 mg tablets.
It is available on prescription only as tablets for oral use, but the online pharmacy, will sell bupropion without prescription.
You may be able to order Zyban from them online and save the local pharmacy markup.
Do not use Zyban and Wellbutrin concurrently, as they contain the same active ingredient.
Take immediate release formulations in equally divided doses (three or four times daily) to avoid risk of seizures. Do not chew or crush the XL or SR formulations.
The bupropion XL formulation may be excreted in the stool. This is an empty shell which is not absorbed. The drug has been absorbed.
Before you order bupropion, you must know that this drug may cause significant sedation and drowsiness, which may impair your ability to perform tasks requiring judgment or motor or cognitive skills. If you experience a seizure while on this medication, stop immediately and report it to your doctor.
What is Zyban?
Bupropion works by inhibiting the activity of certain chemicals in the brain.
Brands & Classes
Wellbutrin, Wellbutrin SR, Wellbutrin XL, Zyban
Antidepressant, smoking deterrent (dopamine-reuptake inhibitor)
Tablets - Oral 150 mg.
Depression: PO 100 mg bid initially, increase based on clinical response to 100 mg tid no sooner than 3 days after initiating therapy, may increase after 1 month to 150 mg tid; no single dose should exceed 150 mg; at least 6 hr should elapse between doses; or PO Sus Action 150 mg bid, may increase several weeks later to 200 mg bid if no improvement on 300 mg/d.
Smoking cessation:150 mg Sus Action qd x 3 days; then 150 mg Sus Action bid × 7-12 weeks (target quit date to follow 1 week of therapy).