Trimethoprim-sulfamethoxazole belongs to a class of drugs known as sulfonamide antibiotics. Bactrim tablets contain a combination of two antibiotic drugs: trimethoprim and sulfamethoxazole, and is approved for a wide variety of bacterial infections. As an off-label treatment, this drug combination is considered first-line therapy for both skin and body-system nocardiosis; it works by blocking bacterial growth.
Original uses (on-label)
Treatment of various infections due to susceptible bacteria.
Potential side effects
Rash, itching, nausea, vomiting, stomach upset, various blood disorders (decreased red blood cells, decreased white blood cells, etc.), fever, changes in kidney or liver function, local injection site reaction (injection), anorexia, severe skin reactions.
- Notify your doctor if you are allergic to sulfa drugs or sulfites, or have certain types of anemia (megaloblastic anemia due to folate deficiency).
- Not for use in infants less than two months of age, pregnant women at term, or women nursing infants less than two months of age.
- This drug may cause severe skin reactions, that although rare, may cause death. Discontinue this drug at the first sign of rash and notify your doctor immediately.
- Rash, sore throat, fever, joint pain, pallor, unusual bleeding or bruising, jaundice may be an early sign of serious reactions.
- Report any cough, shortness of breath may be indicative of a hypersensitivity reaction to the respiratory tract.
- Not for use in the treatment of group A beta-hemolytic streptococcal infections.
- Report chronic, persistent diarrhea that develops during or shortly after the completion of therapy.
- Before you order Bactrim, please notify your doctor if you have impaired kidney or liver function.
Phenytoin, warfarin, cyclosporine, dapsone, diuretics, methotrexate, sulfonylureas, zidovudine.
Pregnancy and breast-feeding cautions
Pregnancy category C; do not use at term, may cause kernicterus in the neonate; not recommended in the neonatal nursing period because sulfonamides excreted in breast milk may cause kernicterus.
Where can I buy Bactrim without prescription?
This medication is a prescription drug that comes in 480 mg, 960 mg tablets.
It is available on prescription only as tablets for oral use, but the online pharmacy, will sell Bactrim without prescription.
You may be able to order Bactrim antibiotic from them online and save the local pharmacy markup.
Maintain adequate fluid intake.
A variety of patient case study reports document the efficacy of Bactrim in nocardiosis.
In a study by researchers from the Czech Republic, trimethoprimsulfamethoxazole in combination with antibiotics drugs such as cefotaximine, amikacin, chloramphenicol, and doxycycline successfully treated disseminated nocardiosis in the skin, right kidney, liver, peritoneal cavity, lungs, and thigh in a 55-year-old woman with mild trauma to the arm.
The researchers noted that the combination of trimethoprimsulfamethoxazole and doxycycline was beneficial.
In another study, five cases of Nocardia infection were noted among 301 patients who received bone marrow transplant. Treatment consisted of Bactrim, ceftriaxone (an antibiotic), or carbapenem (an antibiotic).
This regimen resulted in a one-year survival of 40%, and all patients who received more than two weeks of treatment were cured of their infections.
What is Bactrim?
This drug fights bacterial growth by affecting bacterial metabolism of folinic acid and dihydrofolic acid; this interferes with the production of specific proteins in the bacteria.
Brands & Classes
Septra, Bactrim, Antrima
Dihydrofolate reductase inhibitor (trimethoprim); sulfonamide derivative (sulfamethoxazole)
Tablets - Oral 480 mg, 960 mg.
UTIs, shigellosis, acute exacerbations of chronic bronchitis, acute otitis media: PO 160 mg TMP/800 mg SMX q12h for 10-14 days (3 days for uncomplicated cystitis in otherwise healthy females, 5 days for shigellosis).
Traveler's diarrhea: PO 160 mg TMP/800 mg SMX q12h for 5 days.
Pneumocystis carinii pneumonitis: PO 20 mg TMP/kg/day divided q6h for 14 days.
Pneumocystis carinii pneumonia prophylaxis: PO 160 mg TMP/800 mg SMX qd or 3 x /wk.
Dosage adjustment for impaired renal function: CrCl >30 ml/min, usual regimen; CrCl 15-30 ml/min, 1/2 usual regimen; CrCl <15 ml/min, not recommended.
UTIs, shigellosis, and acute otitis media: PO 8 mg TMP/kg/day divided q12h (1 ml/kg susp divided q12h).
Pneumocystis carinii pneumonitis: PO 15-20 mg TMP/kg/day divided q6h for 14 days.