Lamisil is indicated for the treatment of a fungal infection of fingernails and toenails due to tinea unguium. It acts by inhibiting the enzyme, squalene oxidase which blocks the synthesis of bacterial and fungal cell walls thus preventing growth.
Tablets: The recommended adult dose is 250 mg daily except in those with reduced liver or kidney function where dose may need to be adjusted.
Cream: To be applied once or twice daily. The affected areas should be cleaned and dried thoroughly before application of the cream. The cream should be applied to the affected skin and surrounding area in a thin layer and rubbed in lightly.
Spray: The spray is applied once or twice daily, depending on the condition being treated. The affected areas should be cleaned and dried thoroughly before application of the spray. A sufficient amount of solution should be applied to wet the treatment area thoroughly, and to cover the affected skin and surrounding area.
Original uses (on-label)
Tinea cruris, tinea corporis, tinea pedis; onychomycosis due to dermatophytes; cutaneous candidiasis; tinea versicolor; active against Epidermophyton floccosum, Trichophyton mentagrophytes, Trichophyton rubrum.
Mechanism of action
Inhibits fungal sterol biosynthesis, causing accumulation of squalene within the fungal cell and cell death.
Potential side effects
You should be aware of potential side effects before you buy terbinafine.
Tablets: In general the drug is well tolerated. Side effects are mild to moderate, and temporary. The most common side effects are fullness, loss of appetite, heartburn, nausea, mild abdominal pain, diarrhea, rash and hives.
Cream and Spray: Redness, itching, or stinging occasionally occur at the site of application, however treatment rarely has to be stopped for this reason.
- Children <12 (safety and efficacy not established).
- Terbinafine should be kept out of the reach of children.
- Report to the doctor any signs or symptoms of liver problems while on this drug including: unusual fatigue, loss of appetite, yellowing of skin or eyes, dark urine, pale stools and itching, or sore throat and fever.
- Use with caution in psoriasis.
- Terbinafine spray and cream are for external use only. Contact with the eyes should be avoided. The spray should not be used on the face. In case of accidental contact with the eyes, rinse eyes thoroughly with running water and consult a doctor if any symptoms persist. In case of inhalation, contact a doctor if any symptoms develop and persist.
Caffeine, cimetidine, cyclosporine, dextromethorphan, rifampin.
Cola nut, guarana, yerba mate, tea (black, green) coffee
Pregnancy and breast-feeding cautions
Pregnancy category B. There is very limited experience with terbinafine in pregnant women, therefore unless the potential benefits outweigh potential risks, generic lamisil tablets should not be used during pregnancy.
Terbinafine is excreted in breast milk. Mothers receiving lamisil tablets should not breastfeed. Use of the spray or cream is unlikely to affect the baby.
Where can I buy Lamisil without prescription?
Lamisil is available on prescription only, but the online drugstore, will sell Terbinafine without prescription.
You may be able to order Lamisil from them online and save the local pharmacy markup.