Misoprostol inhibits the secretion of acid in the stomach and protects the delicate mucosal lining of the stomach. It does this by increasing bicarbonate and mucus production and is used to help prevent gastric ulcers in people who are taking nonsteroidal anti-inflammatory drugs. It can also cause uterine contractions and is also approved for use with mifepristone to help induce abortion in early pregnancy.
Original uses (on-label)
Prevention of NSAID-induced gastric ulcers. Medical termination of pregnancy at less than 49 days. (Used in conjunction with mifepristone. Labeled use in mifepristone package insert.)
Does not reduce the risk of duodenal ulcers during NSAID therapy.
Ulcer therapy: Not to be used in pregnant women or women of childbearing potential unless woman is capable of complying with effective contraceptive measures. Requires negative pregnancy test two weeks prior to the initiation of therapy, oral and written warnings of the risks of this drug must be provided prior to initiation of therapy. Initiate therapy only on the second or third day of the next normal menstrual period.
Diarrhea is dose related and usually occurs early in the course of therapy, typically resolving with continued therapy, but sometimes requires stopping the drug.
Incidence of diarrhea may be lessened by taking right after meals.
Pregnancy and breast-feeding cautions
FDA Pregnancy Risk Category X. Misoprostol induces abortion after oral or vaginal administration early in pregnancy through its potent uterine stimulant effects. However, when used later during second and third trimesters, it is been shown efficacious for labor induction and cervical ripening. If you buying cytotec, you should also know, that this drug should not be used during breast-feeding because of the potential for severe diarrhea in the nursing infant.
Ulcer Therapy: Requires written and oral patient counseling. Begin therapy only on second or third day of the next normal menstrual period. If you're planning to buy misoprostol online, please remember that this drug has a black box warning regarding its abortifacient properties. Uterine rupture has been reported when this drug has been used to induce labor or abortion beyond the eighth week of pregnancy.
Where can I buy Cytotec without prescription? Cytotec is a prescription drug that comes in 100 mcg, 200 mcg tablets. It is available on prescription only as tablets for oral use, but the online pharmacy, will sell Misoprostol without prescription. You may be able to order Cytotec from them online and save the local pharmacy markup.
Misoprostol in the treatment of chronic constipation
Patients can order misoprostol to treat chronic constipation. According to Off-Label Drug Facts, cytotec may also induce abdominal cramping and diarrhea in some people. This secondary effect may result from multiple factors, including changes in bicarbonate balance. As a result, cytotec has been tried as a treatment for chronic constipation.
Digestive Disease Science reported on a trial in nine patients who had bowel movements only every four days. They were divided to receive cytotec or a placebo three times a day for one week, then no drug for one week, then the opposite therapy for one week. Movement of food through the colon was normalized in 78% of patients after misoprostol treatment and significantly decreased compared to placebo (66 vs. 109.4 hours). Researchers observed that frequency of bowel movements significantly increased from 2.5 to 6.5 in those receiving this drug.
What is Cytotec?
This drug replaces the protective prostaglandins that are destroyed during prostaglandin-inhibiting therapies (NSAIDs). It has also been shown to induce uterine contractions.
Brands & Classes
Brand name Cytotec, Zitotec, MissKayGeneric name MisoprostolChemical class Prostaglandin e1 analog Therapeutic class Abortifacient; gastrointestinal protectant
Tablets - Oral 100 mcg, 200 mcg.
ADULT Gastric ulcer prophylaxis: PO 200 mcg qid with food for duration of NSAID therapy; if drug not tolerated, decrease to 100 mcg qid or 200 mcg bid