Baclofen (Lioresal)

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Relieves muscle spasticity by inhibiting the transmission of reflexes at the spinal cord level.
Original uses (on-label)
Treatment of reversible spasticity associated with multiple sclerosis or spinal cord lesions and used intrathecally to treat intractable spasticity associated with spinal cord injury, multiple sclerosis, and other spinal disease (spinal ischemia or tumor, transverse myelitis, cervical spondylosis, degenerative myelopathy)
Newly discovered uses (off-label)
Alcoholism (cravings & dependency), alcohol withdrawal, cluster headache treatment and prevention, cocaine addiction, Gilles de la Tourette syndrome, hiccups, migraine prevention, tension headache prevention
Potential side effects
Drowsiness, vertigo, dizziness, psychiatric disturbances, and muscular weakness.
  • Avoid abrupt discontinuation of the drug.
  • Before you buy baclofen, please remember that this drug not for use in the elderly. The elderly are more likely to have central nervous system side effects at higher doses.
  • Should be free of infection prior to receiving intrathecal injection with this drug.
  • Dosage reduction may be necessary in patients with reduced kidney function.
  • May aggravate symptoms of psychiatric disorders (e.g., schizophrenia, confusion, psychosis).
Drug interactions
Other drugs that cause depression of the central nervous system. Check with your pharmacist or doctor before starting new therapy.
Food interactions
Avoid alcohol.
Herbal interactions
Valerian, St. John's wort, kava kava, and gotu kola.
Pregnancy and breast-feeding cautions
FDA Pregnancy Risk Category C. Baclofen is excreted into breast milk. The American Academy of Pediatrics classifies it as compatible with breast-feeding.
Special information
This drug has a black box warning regarding the abrupt withdrawal of intrathecal lioresal. Sudden discontinuation may result in severe complications, including fever, rebound/exaggerated spasticity, muscle rigidity and severe muscle and kidney toxicity, which can lead to organ failure and possibly death.

Buy Baclofen

Where can I order Lioresal?
Lioresal is a prescription drug that comes in 10 mg, and 25 mg tablets. Lioresal is prescription-only, but the internet drugstore, will sell it without prescription. You may be able to order Baclofen from them online and save the local pharmacy markup.
Alcohol withdrawal
Baclofen has been used in a number of instances to reduce alcohol cravings. In animal studies, this drug has suppressed the severity of alcohol withdrawal. It suppressed the intensity of alcohol withdrawal syndrome in rats physically dependent on alcohol. Also, researchers in Italy examined the effects of this drug in humans in a small case study series for 30 days. With the use of baclofen, all patients experienced a rapid reduction in symptoms as shown by reduced withdrawal scores and reductions in blood pressure and pulse rates. After 30 days, all patients were without withdrawal symptoms and alcohol-free. Lioresal was well tolerated; three patients experienced transient drowsiness within 30 to 60 minutes after lioresal administration during the first week of treatment. Researchers concluded that baclofen, in a dose lower than that for the treatment of muscle spasms, produced a rapid disappearance of alcohol withdrawal in all five people in this study.
What is Baclofen?
Baclofen tablets belong to a class of drugs known as muscle relaxants; it is used to relieve muscle spasms and contractions in conditions such as multiple sclerosis.
Brands & Classes
Brand name
Kemstro, Lioresal, Riclofen, Liofen
Generic name
Chemical class
GABA chlorophenyl derivative
Therapeutic class
Skeletal muscle relaxant
Avail forms
Tablets - Oral 10 mg, 25 mg.
order baclofen
PO 5 mg tid x 3 days, then 10 mg tid x 3 days, then 15 mg tid x 3 days, then 20 mg tid x 3 days, then titrated to response, not to exceed 80 mg/day

2-7 yr: initial: PO 10-15 mg/24 hr divided q8h; titrate dose every 3 days in increments of 5-15 mg/day to a max of 40 mg/day
>8 yr: PO max 60 mg/day in 3 divided doses